Article

Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development

2018-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Pleomorphic adenoma gene 1 (PLAG1) is a transcription factor involved in cancer and growth. We discovered a de novo DNA motif containing a PLAG1 binding site in the promoters of genes activated during zygotic genome activation (ZGA) in human embryos. This motif was located within an Alu element in a region that was conserved in the murine B1 element. We show that maternally provided Plag1 is e...

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Literature Corpus work: 40320a74-39cb-5525-883e-a60a83902f6c
DOI: 10.1101/305375

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