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LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos

1 Jun 2024

Abstract excerpt

Emerging evidence highlights the regulatory role of paired-like (PRD-like) homeobox transcription factors (TFs) in embryonic genome activation (EGA). However, the majority of PRD-like genes are lost in rodents, thus prompting an investigation into PRD-like TFs in other mammals. Here, we showed that PRD-like TFs were transiently expressed during EGA in human, monkey, and porcine fertilized embryos, yet they...

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PMID: 38878289
DOI: 10.1016/j.celrep.2024.114372

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