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Article

Complex functions of Gcn5 and Pcaf in development and disease.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Feb 2021

Koutelou Evangelia, Farria Aimee T, Dent Sharon Y R

Abstract excerpt

A wealth of biochemical and cellular data, accumulated over several years by multiple groups, has provided a great degree of insight into the molecular mechanisms of actions of GCN5 and PCAF in gene activation. Studies of these lysine acetyltransferases (KATs) in vitro, in cultured cells, have revealed general mechanisms for their recruitment by sequence-specific binding factors and their molecular functions as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32730897
DOI: 10.1016/j.bbagrm.2020.194609
PMCID: PMC7854485

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