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Human zygotic genome activation is initiated from paternal genome

30 Jan 2023

Abstract excerpt

Although parental genomes undergo extensive epigenetic reprogramming to be equalized after fertilization, whether they play different roles in human zygotic genome activation (ZGA) remains unknown. Here, we mapped parental transcriptomes by using human parthenogenetic (PG) and androgenetic (AG) embryos during ZGA. Our data show that human ZGA is launched at the 8-cell stage in AG and bi-parental embryos, but at...

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Epigenetics and DNA Methylation
Genetic Syndromes and Imprinting
Prenatal Screening and Diagnostics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36717546
DOI: 10.1038/s41421-022-00494-z

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