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Article

Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.

Journal of molecular neuroscience : MN - 1 Sept 2016

Wei Gengze, Deng Xinxian, Agarwal Saurabh, Iwase Shigeki, Disteche Christine, Xu Jun

Abstract excerpt

The X-linked lysine (K)-specific demethylase 5C (KDM5C) gene plays an important role in brain development and behavior. It encodes a histone demethylase that is involved in gene regulation in neuronal differentiation and morphogenesis. When mutated, it causes neuropsychiatric symptoms, such as intellectual disability, delayed language development, epilepsy, and impulsivity. To better understand how the patient...

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Identifiers

PMID: 27421841
DOI: 10.1007/s12031-016-0770-3
PMCID: PMC5412133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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