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Article

WNT signalling control by KDM5C during development affects cognition.

Nature - 1 Mar 2024

Karwacki-Neisius Violetta, Jang Ahram, Cukuroglu Engin, Tai Albert, Jiao Alan, Predes Danilo, Yoon Joon, Brookes Emily, Chen Jiekai, Iberg Aimee, Halbritter Florian, Õunap Katrin, Gecz Jozef, Schlaeger Thorsten M, Ho Sui Shannan, Göke Jonathan, He Xi, Lehtinen Maria K, Pomeroy Scott L, Shi Yang

Abstract excerpt

Although KDM5C is one of the most frequently mutated genes in X-linked intellectual disability1, the exact mechanisms that lead to cognitive impairment remain unknown. Here we use human patient-derived induced pluripotent stem cells and Kdm5c knockout mice to conduct cellular, transcriptomic, chromatin and behavioural studies. KDM5C is identified as a safeguard to ensure that neurodevelopment occurs at an...

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Source

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Identifiers

PMID: 38383780
DOI: 10.1038/s41586-024-07067-y
PMCID: PMC10954547

Genes

KDM5C
WNT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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