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Article

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

3 Jan 2019

Abstract excerpt

Induction of differentiation is a therapeutic strategy in high-risk neuroblastoma, a childhood cancer of the sympathetic nervous system. Neuroblastoma differentiation requires transcriptional upregulation of neuronal genes. How this process is regulated at epigenetic levels is not well understood. Here we report that the histone H3 lysine 27 demethylase KDM6B is an epigenetic activator of neuroblastoma cell...

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PMID: 30631055
DOI: 10.1038/s41389-018-0112-0

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