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Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice

5 Oct 2012

Abstract excerpt

Reconstitution of female germ cell development in vitro is a key challenge in reproductive biology and medicine. We show here that female (XX) embryonic stem cells and induced pluripotent stem cells in mice are induced into primordial germ cell-like cells (PGCLCs), which, when aggregated with female gonadal somatic cells as reconstituted ovaries, undergo X-reactivation, imprint erasure, and cyst formation, and...

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PMID: 23042295
DOI: 10.1126/science.1226889

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