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Roadmap of germline development and in vitro gametogenesis from pluripotent stem cells

9 Nov 2019

Abstract excerpt

BACKGROUND: The germ cell lineage is a fundamental component of the metazoan life cycle, ensuring the perpetuation and substantial diversification of genetic information across generations. Recent advances in the understanding of mouse germ cell development have culminated in the ability to reconstitute gametogenesis in vitro, thereby enabling the biochemical and molecular analyses of germ cell specification and...

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PMID: 31705609
DOI: 10.1111/andr.12726

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