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Article

Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity

24 Mar 2012

Abstract excerpt

Neuropsychiatric disorders characterized by behavioral disinhibition, including disorders of compulsivity (e.g. obsessive-compulsive disorder; OCD) and impulse-control (e.g. impulsive aggression), are severe, highly prevalent and chronically disabling. Treatment options for these diseases are extremely limited. The pathophysiological bases of disorders of behavioral disinhibition are poorly understood but it has...

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PMID: 22443164
DOI: 10.1111/j.1471-4159.2012.07739.x

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