Article

Exploring the Antifibrotic Potential of the heparan sulfate mimetic OTR4120: Insights from Preclinical Models

2024-10-18

Abstract excerpt

<h4>Rationale</h4> Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease characterized by excessive deposition of extracellular matrix (ECM), resulting in lung function impairment. Heparan sulfate mimetics (HSm) have been suggested to have potential antifibrotic effects by regulating ECM. This study aims to investigate the impact of a specific HSm named OTR4120 on fibrotic processes in ex vivo , in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e797c514-e5ea-5948-be6c-145659485d2a
DOI: 10.1101/2024.10.17.618798

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring the Antifibrotic Potential of the heparan sulfate mimetic OTR4120: Insights from Preclinical ModelsDOI 10.1101/2024.10.17.618798Read

A noble TGFβ biogenesis inhibitor exhibits both potent anti-fibrotic and anti-inflammatory capabilitiesSemantic proximity Read

Tankyrase inhibition demonstrates anti-fibrotic effects in preclinical pulmonary fibrosis modelsSemantic proximity Read

Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2Semantic proximity Read

Fibrotic human lung extracellular matrix as a disease-specific substrate for 3D <i>in-vitro</i> models of pulmonary fibrosisSemantic proximity Read

An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis.Semantic proximity Read

CCN3-derived peptide BLR-200 impairs YAP activation and attenuates bleomycin-induced skin fibrosis through blocking the generation of Sfrp2-positive fibroblastsSemantic proximity Read

Expression, localization and anti-fibrotic effect of HSPG2 in idiopathic pulmonary fibrosisSemantic proximity Read

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic OrganoidsSemantic proximity Read

Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis.Semantic proximity Read

Bone Morphogenetic Protein–Inducer Tilorone Identified by High-Throughput Screening Is Antifibrotic <i>In Vivo</i>Semantic proximity Read

Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis.Semantic proximity Read

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosisSemantic proximity Read