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Article

Time and phenotype-dependent transcriptome analysis in AAV-TGFβ1 and Bleomycin-induced lung fibrosis models.

Scientific reports - 16 Jul 2022

Strobel Benjamin, Klein Holger, Leparc Germán, Stierstorfer Birgit E, Gantner Florian, Kreuz Sebastian

Abstract excerpt

We have previously established a novel mouse model of lung fibrosis based on Adeno-associated virus (AAV)-mediated pulmonary overexpression of TGFβ1. Here, we provide an in-depth characterization of phenotypic and transcriptomic changes (mRNA and miRNA) in a head-to-head comparison with Bleomycin-induced lung injury over a 4-week disease course. The analyses delineate the temporal state of model-specific and...

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Identifiers

PMID: 35842487
DOI: 10.1038/s41598-022-16344-7
PMCID: PMC9288451

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