Article

Deciphering Tumor Microenvironment Dynamics in Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma using Single-cell RNA Sequencing

2025-12-01

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) exhibits profound inter-tissue heterogeneity, yet how immune and stromal ecosystems diverge between primary tumors and metastatic lymph nodes remains poorly understood. Here, we generated a single-cell atlas of 344,790 cells and paired T cell receptor profiles from primary tumor mucosa, adjacent mucosa, non-metastatic lymph nodes, and metastatic lymph nodes from 18 patient...

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Identifiers and source

Literature Corpus work: 168437a5-deaf-534e-937c-1dfcc31d03e5
DOI: 10.1101/2025.11.27.690370

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