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Article

Understanding the cellular origin and progression of esophageal cancer using esophageal organoids.

Cancer letters - 1 Jul 2021

Sachdeva Uma M, Shimonosono Masataka, Flashner Samuel, Cruz-Acuña Ricardo, Gabre Joel T, Nakagawa Hiroshi

Abstract excerpt

Three-dimensional (3D) organoids are a novel tool to model epithelial cell biology and human diseases of the esophagus. 3D organoid culture systems have been utilized to investigate the pathobiology of esophageal cancer, including both squamous cell carcinoma and adenocarcinoma. Additional organoid-based approaches for study of esophageal development and benign esophageal diseases have provided key insights into...

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Identifiers

PMID: 33838281
DOI: 10.1016/j.canlet.2021.03.031
PMCID: PMC8493518

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