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Article

Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.

Proceedings of the National Academy of Sciences of the United States of America - 23 Feb 2010

Laursen Nick S, Gordon Natasha, Hermans Stefan, Lorenz Natalie, Jackson Nicola, Wines Bruce, Spillner Edzard, Christensen Jesper B, Jensen Morten, Fredslund Folmer, Bjerre Mette, Sottrup-Jensen Lars, Fraser John D, Andersen Gregers R

Abstract excerpt

Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have isolated a stable IgA-SSL7-C5 complex, and our crystal structure of the C5-SSL7 complex confirms that binding to C5 occurs exclusively through the C-terminal...

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Share to Complement C5
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20133685
DOI: 10.1073/pnas.0910565107
PMCID: PMC2840425

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