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Article

Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel 'close, dock, lock and latch' mechanism for complement evasion.

The Biochemical journal - 4 May 2017

Zhang Yingjie, Wu Minhao, Hang Tianrong, Wang Chengliang, Yang Ye, Pan Weimin, Zang Jianye, Zhang Min, Zhang Xuan

Abstract excerpt

Complement factor H (CFH) is a soluble complement regulatory protein essential for the down-regulation of the alternative pathway on interaction with specific markers on the host cell surface. It recognizes the complement component 3b (C3b) and 3d (C3d) fragments in addition to self cell markers (i.e. glycosaminoglycans, sialic acid) to distinguish host cells that deserve protection from pathogens that should be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28258151
DOI: 10.1042/BCJ20170085
PMCID: PMC5415847

Genes

CFH

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