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Article

Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi.

The Journal of biological chemistry - 8 Aug 2008

Upadhyay Abhishek, Burman Julia D, Clark Elizabeth A, Leung Elisa, Isenman David E, van den Elsen Jean M H, Bagby Stefan

Abstract excerpt

Among the recently discovered Staphylococcus aureus immune evasion proteins, Sbi is unique in its ability to interact with components of both the adaptive and innate immune systems of the host. Sbi domains I and II (Sbi-I and Sbi-II) bind IgG. Sbi domain IV (residues 198-266) binds the central complement protein C3. When linked to Sbi-III, Sbi-IV induces a futile consumption of complement via alternative pathway...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18550524
DOI: 10.1074/jbc.M802636200
PMCID: PMC2494919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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