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Article

Strategies to Overcome or Circumvent P-Glycoprotein Mediated Multidrug Resistance

31 Jan 2008

Abstract excerpt

Cancer patients who receive chemotherapy often experience intrinsic or acquired resistance to a broad spectrum of chemotherapeutic agents. The phenomenon, termed multidrug resistance (MDR), is often associated with the over-expression of P-glycoprotein, a transmembrane protein pump, which can enhance efflux of a various chemicals structurally unrelated at the expense of ATP depletion, resulting in decrease of the...

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PMID: 18289002
DOI: 10.2174/092986708783503258

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