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Article

Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer

18 Sept 2017

Abstract excerpt

Chemotherapy is an essential part of anticancer treatment. However, the overexpression of P-glycoprotein (P-gp) and the subsequent emergence of multidrug resistance (MDR) hampers successful treatment clinically. P-gp is a multidrug efflux transporter that functions to protect cells from xenobiotics by exporting them out from the plasma membrane to the extracellular space. P-gp inhibitors have been developed in an...

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PMID: 29062386
DOI: 10.3332/ecancer.2017.768

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