Article
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2001
Kondratov R V, Komarov P G, Becker Y, Ewenson A, Gudkov A V
Abstract excerpt
By screening a chemical library for the compounds protecting cells from adriamycin (Adr), a series of small molecules was isolated that interfered with the accumulation of Adr in mouse fibroblasts by enhancing efflux of the drug. Isolated compounds also stimulated efflux of Rhodamine 123 (Rho-123), another substrate of multidrug transporters. Stimulation of drug efflux was detectable in the cells expressing...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibiotics, Antineoplastic
- Cell Line
- Doxorubicin
- Drug Evaluation, Preclinical
- Drug Resistance, Multiple
- Fibroblasts
- Imidazoles
- Mice