Article

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse

2022-08-23

Abstract excerpt

<title>Abstract</title> <p>Background: Huntington’s disease (HD) is a neurodegenerative disease that involves a complex combination of psychiatric, cognitive and motor impairments. Synaptic dysfunction has been implicated in HD pathogenesis. However, the mechanisms have not been clearly delineated. Synaptic vesicular zinc is closely linked to modulating synaptic transmission and maintaining cognitive ability. It...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fde32a6-ede0-5b80-b4a1-80fa5f83e9e7
DOI: 10.21203/rs.3.rs-29099/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouseDOI 10.21203/rs.3.rs-29099/v2Read

Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?Semantic proximity Read

Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.Semantic proximity Read

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.Semantic proximity Read

Elevation of zinc transporter ZnT3 protein in the cerebellar cortex of the AbetaPP/PS1 transgenic mouse.Semantic proximity Read

Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene by AAV9 obviates lipid phenotypes in brain and plasma of zQ175DN HD miceSemantic proximity Read

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.Semantic proximity Read

Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressorsSemantic proximity Read

Vesicular Zinc Modulates Cell Proliferation and Survival in the Developing HippocampusSemantic proximity Read

Huntingtin is essential for synaptic plasticity in the adult hippocampusSemantic proximity Read

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal CircuitsSemantic proximity Read

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem CellsSemantic proximity Read

BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's diseaseSemantic proximity Read