Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.

Molecular biology of the cell - 1 Jan 2005

Seong E, Wainer B H, Hughes E D, Saunders T L, Burmeister M, Faundez V

Abstract excerpt

Neurons express adaptor (AP)-3 complexes assembled with either ubiquitous (beta3A) or neuronal-specific (beta3B) beta3 isoforms. However, it is unknown whether these complexes indeed perform distinct functions in neuronal tissue. Here, we explore this hypothesis by using genetically engineered mo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendrites
Share to Gene Targeting
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Subcellular Fractions

Share to Synapses

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 15537701
DOI: 10.1091/mbc.e04-10-0892
PMCID: PMC539158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15537701-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.PMID 15537701Read ↗

Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles.Semantic proximity Read ↗

Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion.Semantic proximity Read ↗

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.Semantic proximity Read ↗

Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor.Semantic proximity Read ↗

Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.Semantic proximity Read ↗

Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?Semantic proximity Read ↗

Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.Semantic proximity Read ↗

Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.Semantic proximity Read ↗

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouseSemantic proximity Read ↗

Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.Semantic proximity Read ↗

Physiological roles of clathrin adaptor AP complexes: lessons from mutant animals.Semantic proximity Read ↗

Neuronal functions of adaptor complexes involved in protein sorting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.