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Article

Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.

Journal of neuropathology and experimental neurology - 1 Mar 2012

Lee Joo-Yong, Cho Eunsil, Seo Jung-Woo, Hwang Jung Jin, Koh Jae-Young

Abstract excerpt

Synaptic vesicle Zn is regulated by zinc transporter 3 (ZnT3) and is involved in neurotransmission and synaptic plasticity. Here, we describe extensive alterations of ZnT3-regulated Zn pools in the brains of human amyloid precursor protein-transgenic (Tg2576) mice. In contrast to wild-type littermates in which ZnT3 expression and synaptic Zn increased with age, there were age-dependent reductions in ZnT3...

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PMID: 22318122
DOI: 10.1097/NEN.0b013e3182417387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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