Article

Advancing Clinical Implementation of Cardiovascular Polygenic Risk Scores Through Patient-Level Robustness Assessment

2026-06-11

Abstract excerpt

<h4>Background and Aims</h4> Polygenic risk scores (PRSs) for atherosclerotic cardiovascular disease (ASCVD) can perform equivalently at the population level yet disagree for individual patients. We examined whether such intra-individual variability reflects genuinely complementary risk information or mainly statistical and methodological uncertainty, and whether it affects clinical classification once PRSs are i...

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Literature Corpus work: 3fddcef7-ae2e-5a1c-a0bc-9bb72270cfd4
DOI: 10.64898/2026.06.10.26355357

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