Article

iPRSue: Unbiased individual-level uncertainty estimation in polygenic risk scores

2026-05-14

Abstract excerpt

<title>Abstract</title> <p>Advancements in genomic analytics continue to improve the accuracy and clinical relevance of polygenic risk scores (PRSs). While quantifying uncertainty in individual PRS estimates is essential for clinical decision-making, existing tools offer limited capabilities in this area, hindering broader clinical adoption. Shrinkage methods help reduce overfitting and improve predictive perform...

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Literature Corpus work: e70cf248-bdfc-59bd-92b2-155ab25e3d19
DOI: 10.21203/rs.3.rs-9603315/v1

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