Article

Characterizing the Uncertainty, Misclassification and Inconsistency of Polygenic Prediction

2026-05-13

Abstract excerpt

Polygenic risk scores (PRSs) hold promise for precision medicine, yet their clinical translation is hindered by substantial uncertainty in individual risk estimates and often limited agreement in risk stratification across multiple PRSs for the same disease. We develop a unified inferential framework to calibrate PRS point estimates and uncertainties for both quantitative traits and binary phenotypes, and to chara...

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Literature Corpus work: 34908d45-d8d8-5525-a318-405b99855088
DOI: 10.64898/2026.05.11.26352897

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