Article

Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington’s disease

2026-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Human and mouse genetics have established mismatch repair (MMR) as a central mediator of somatic repeat expansion, a key pathogenic process in Huntington’s disease (HD) and related disorders. How individual MMR components function within the intact mammalian brain and interact with broader cellular networks remains poorly understood. We screened more than 500 chemically stabilized siRNAs targeti...

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Literature Corpus work: 79bb4fc2-0775-560a-9470-6d5fea8daa14
DOI: 10.64898/2026.06.19.733435

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