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Metabolome-wide association study on <i>ABCA7</i> demonstrates a role for ceramide metabolism in impaired cognitive performance and Alzheimer’s disease

2021-04-09

Abstract excerpt

Genome-wide association studies (GWAS) have identified genetic loci associated with risk of Alzheimer’s disease (AD), but underlying mechanisms are largely unknown. We conducted a metabolome-wide association study (MWAS) of AD-associated loci from GWAS using untargeted metabolic profiling (metabolomics) by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). We identified an association of lactosyl...

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Literature Corpus work
3fc94c25-491c-5010-b0bc-ad079dc2ae0a
DOI
10.1101/2021.04.06.21254991
Open publication

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Metabolome-wide association study on <i>ABCA7</i> demonstrates a role for ceramide metabolism in impaired cognitive performance and Alzheimer’s diseaseDOI 10.1101/2021.04.06.21254991
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