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Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer’s disease

21 Oct 2022

Abstract excerpt

Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer’s disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study (MWAS) of AD-associated loci from GWASs using untargeted metabolic profiling (metabolomics) by ultraperformance liquid chromatography–mass spectrometry (UPLC-MS). We...

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PMID: 36269859
DOI: 10.1073/pnas.2206083119

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