Article
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia
22 Jul 2022
Abstract excerpt
Abstract Background Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein remains nebulous. The association between E3 ubiquitin ligase and spastin provides a potential therapeutic strategy. Results As evidenced by protein chip analysis, FBXL17 inversely...
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