Article

FBXL17/Spastin Axis As A Novel Therapeutic Target of Hereditary Spastic Paraplegia

2022-03-30

Abstract excerpt

<h4>Background: </h4> Spastin significantly influences microtubule regulation in neurons and is implicated in the pathogenesis of hereditary spastic paraplegia (HSP). However, post-translational regulation of the spastin protein remains nebulous. The association between E3 ubiquitin ligase and spastin provides a potential therapeutic strategy. <h4>Results: </h4> As evidenced by protein chip analysis, FBXL17 invers...

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Literature Corpus work: 2675d40d-8e1f-538b-b9b1-56176edbb77f
DOI: 10.21203/rs.3.rs-1403859/v1

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