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Haploinsufficiency of the psychiatric risk gene <i>Cyfip1</i> causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

2018-09-14

Abstract excerpt

Genetic risk factors can significantly increase chances of developing psychiatric disorders, but the underlying biological processes through which this risk is effected remain largely unknown. Here we show that haploinsufficiency of Cyfip1, a candidate risk gene present in the pathogenic 15q11.2(BP1-BP2) deletion may impact on psychopathology via abnormalities in cell survival and migration of newborn neurons duri...

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Literature Corpus work
e668386f-31ee-5b44-8ce8-8c8e3dbf8f1f
DOI
10.1101/417832
Open publication

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Haploinsufficiency of the psychiatric risk gene <i>Cyfip1</i> causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanismsDOI 10.1101/417832
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