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The enigma of DNA methylation in the mammalian oocyte

25 Feb 2020

Abstract excerpt

The mammalian genome experiences profound setting and resetting of epigenetic patterns during the life-course. This is understood best for DNA methylation: the specification of germ cells, gametogenesis, and early embryo development are characterised by phases of widespread erasure and rewriting of methylation. While mitigating against intergenerational transmission of epigenetic information, these processes must...

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PMID: 32148772
DOI: 10.12688/f1000research.21513.1

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