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Article

The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.

PLoS genetics - 1 May 2021

Kibe Kanako, Shirane Kenjiro, Ohishi Hiroaki, Uemura Shuhei, Toh Hidehiro, Sasaki Hiroyuki

Abstract excerpt

DNA methylation at CG sites is important for gene regulation and embryonic development. In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A. DNMT3A has a PWWP domain, which recognizes H3K36me2/3, and heterozygous mutations in this domain, including D329A substitution, cause aberrant CG hypermethylation of regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34048432
DOI: 10.1371/journal.pgen.1009570
PMCID: PMC8162659

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