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The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes

1 Aug 2023

Abstract excerpt

Establishment of a proper DNA methylation landscape in mammalian oocytes is important for maternal imprinting and embryonic development. De novo DNA methylation in oocytes is mediated by the DNA methyltransferase DNMT3A, which has an ATRX-DNMT3-DNMT3L (ADD) domain that interacts with histone H3 tail unmethylated at lysine-4 (H3K4me0). The domain normally blocks the methyltransferase domain via intramolecular...

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PMID: 37527244
DOI: 10.1371/journal.pgen.1010855

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