Article
Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.
Cellular and molecular neurobiology - 1 Jan 2017
Di Pietro Chiara, Marazziti Daniela, La Sala Gina, Abbaszadeh Zeinab, Golini Elisabetta, Matteoni Rafaele, Tocchini-Valentini Glauco P
Abstract excerpt
Cellular primary cilia crucially sense and transduce extracellular physicochemical stimuli. Cilium-mediated developmental signaling is tissue and cell type specific. Primary cilia are required for cerebellar differentiation and sonic hedgehog (Shh)-dependent proliferation of neuronal granule precursors. The mammalian G-protein-coupled receptor 37-like 1 is specifically expressed in cerebellar Bergmann glia...
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