The primary cilium as a cellular signaling center: lessons from disease.

doi:10.1016/j.gde.2009.04.008

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Article

The primary cilium as a cellular signaling center: lessons from disease.

Current opinion in genetics & development - 1 Jun 2009

Lancaster Madeline A, Gleeson Joseph G

Abstract excerpt

Genetic diseases known as ciliopathies have recently entered the limelight, placing new importance on a previously mysterious organelle: the primary cilium. Mutations affecting the primary cilium in both humans and animal models can lead to a plethora of distinct phenotypes including retinal degeneration, kidney cysts, and brain malformations. New findings are quickly lending insight into the functions of this...

Topics

Animals
Bardet-Biedl Syndrome
Biological Transport
Cilia
Genetic Predisposition to Disease
Humans
Kartagener Syndrome
Models, Biological
Polycystic Kidney Diseases
Signal Transduction

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Identifiers

PMID: 19477114
DOI: 10.1016/j.gde.2009.04.008
PMCID: PMC2953615

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