Article

Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastases

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Osteosarcoma is the most common malignant bone tumor in young patients and remains a significant clinical challenge, particularly in the context of metastatic disease. Despite extensive documentation of genomic alterations in osteosarcoma, studies detailing the immunosuppressive mechanisms within the metastatic osteosarcoma microenvironment are lacking. Our objective was to characterize the spat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f559c2b-988d-5933-b83e-5ba4d42be77d
DOI: 10.1101/2025.01.22.631350

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastasesDOI 10.1101/2025.01.22.631350Read

Immunosuppressive tumor microenvironment of osteosarcomaSemantic proximity Read

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cellsSemantic proximity Read

Spatial transcriptomic sequencing of fresh frozen canine osteosarcoma tumor samplesSemantic proximity Read

Novel insights and therapeutic interventions for pediatric osteosarcoma.Semantic proximity Read

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic nicheSemantic proximity Read

A single-cell atlas of cancer-educated ecotypes across high-risk pediatric sarcomasSemantic proximity Read

Single-Cell and Spatial Profiling of Tumor Microenvironment Heterogeneity in Human OsteosarcomasSemantic proximity Read

A single-cell and spatially resolved atlas of human osteosarcomasSemantic proximity Read

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1 <sup>+</sup> /GPNMB <sup>+</sup> myeloid cells with immunosuppressive and tumor-promoting capabilitiesSemantic proximity Read

Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogsSemantic proximity Read

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcomaSemantic proximity Read

Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma.Semantic proximity Read