Article
The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP.
PLoS genetics - 1 Jul 2020
Szeri Flora, Lundkvist Stefan, Donnelly Sylvia, Engelke Udo F H, Rhee Kyu, Williams Charlene J, Sundberg John P, Wevers Ron A, Tomlinson Ryan E, Jansen Robert S, van de Wetering Koen
Abstract excerpt
The membrane protein ANKH was known to prevent pathological mineralization of joints and was thought to export pyrophosphate (PPi) from cells. This did not explain, however, the presence of ANKH in tissues, such as brain, blood vessels and muscle. We now report that in cultured cells ANKH exports ATP, rather than PPi, and, unexpectedly, also citrate as a prominent metabolite. The extracellular ATP is rapidly...
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