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Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia

26 Jun 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate due to late detection. PDAC arises from precursor microscopic lesions, termed pancreatic intraepithelial neoplasia (PanIN), that develop at least a decade before overt disease; this provides an opportunity to intercept PanIN-to-PDAC progression. However, immune interception strategies require full understanding of PanIN and PDAC cellular...

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PMID: 40569674
DOI: 10.1172/jci.insight.191595

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