Article

Identification of novel mutations associated with cycloserine resistance in <i>Mycobacterium tuberculosis</i>

2017-03-05

Abstract excerpt

<h4>Objectives</h4> D-cycloserine (DCS) is an important second-line drug used to treat multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. However, the mechanisms of resistance to DCS are not well understood. Here we investigated the molecular basis of DCS resistance using in vitro isolated resistant mutants of Mycobacterium tuberculosis. <h4>Methods</h4> M. tuberculosis H37Rv was subj...

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Literature Corpus work: b44fc812-4968-57dc-abbd-20abda691c48
DOI: 10.1101/114116

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