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Cytotoxic CD8+ Temra cells show loss of chromatin accessibility at genes associated with T cell activation

2 Feb 2024

Abstract excerpt

As humans age, their memory T cell compartment expands due to the lifelong exposure to antigens. This expansion is characterized by terminally differentiated CD8 + T cells (Temra), which possess NK cell-like phenotype and are associated with chronic inflammatory conditions. Temra cells are predominantly driven by the sporadic reactivation of cytomegalovirus (CMV), yet their epigenomic patterns and cellular...

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Cytomegalovirus and herpesvirus research
Immune Cell Function and Interaction
T-cell and B-cell Immunology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38370415
DOI: 10.3389/fimmu.2024.1285798

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