Article

Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways

2020-07-15

Abstract excerpt

<h4>Summary</h4> The cyclic AMP pathway promotes melanocyte differentiation in part by triggering gene expression changes mediated by CREB and its coactivators (CRTC1-3). Differentiation is dysregulated in melanomas, although the contributions of different cAMP effectors in this setting is unclear. We report a selective differentiation impairment in CRTC3 KO melanocytes and melanoma cells, due to downregulation o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3f1ed326-ab77-58fd-a3da-b24ca3c3ab49
DOI: 10.1101/2020.07.14.202697

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathwaysDOI 10.1101/2020.07.14.202697Read

JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expressionSemantic proximity Read

CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells.Semantic proximity Read

Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility.Semantic proximity Read

Activation of a cAMP Pathway and Induction of Melanogenesis Correlate with Association of p16INK4 and p27KIP1 to CDKs, Loss of E2F-Binding Activity, and Premature Senescence of Human MelanocytesSemantic proximity Read

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathwaySemantic proximity Read

MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progressionSemantic proximity Read

Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formationSemantic proximity Read

Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanomaSemantic proximity Read

Mechanisms Contributing to Differential Regulation of PAX3 Downstream Target Genes in Normal Human Epidermal Melanocytes versus Melanoma CellsSemantic proximity Read

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinomaSemantic proximity Read

MicroRNA-379 mediates pigmentation, migration and proliferation of melanocytes by targeting the insulin-like growth factor 1 receptor.Semantic proximity Read

MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK PathwaysSemantic proximity Read