Article

MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression

2023-03-10

Abstract excerpt

<title>Abstract</title> <p>MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the pathogenesis of melanoma. Although it is widely expressed in different tissue types, its function in non-cutaneous tissue is relatively unknown. Herein, we demonstrate that disruptive <italic>MC1R</italic> variants associated with melanomagenesi...

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Literature Corpus work: ea301491-c8fc-5d2f-9b9b-622c379b61e6
DOI: 10.21203/rs.3.rs-2609170/v1

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