Article

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

2018-09-20

Abstract excerpt

Metastatic melanoma is hallmarked by its ability to switch oncogenic MITF expression. Here we tested the impact of STAT3 on melanoma onset and progression in association with MITF expression levels. We established a mouse melanoma model for deleting Stat3 specifically in melanocytes with specific expression of human hyperactive NRAS Q61K in an Ink4a deficient background. Mice with tissue specific Stat3 deletio...

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Literature Corpus work: dce758c3-538d-5952-ab5f-5cb6596ff24d
DOI: 10.1101/422832

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