Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation

3 Mar 2023

Abstract excerpt

Solar ultraviolet (UV) radiation-induced DNA damage is a major risk factor for skin cancer development. UV-induced redistribution of melanin near keratinocyte nuclei leads to the formation of a supranuclear cap, which acts as a natural sunscreen and protects DNA by absorbing and scattering UV radiation. However, the mechanism underlying the intracellular movement of melanin in nuclear capping is poorly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to melanin and skin pigmentation
Share to Neurobiology and Insect Physiology Research
Share to Skin Protection and Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36869204
DOI: 10.1038/s42003-023-04621-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formationPMID 36869204Read ↗

Distinctive molecular responses to ultraviolet radiation between keratinocytes and melanocytesSemantic proximity Read ↗

Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes.Semantic proximity Read ↗

Melanin’s Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and ProcessingSemantic proximity Read ↗

Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility.Semantic proximity Read ↗

Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathwaysSemantic proximity Read ↗

JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expressionSemantic proximity Read ↗

Mitochondrial calcium signaling mediated transcriptional regulation of keratin filaments is a critical determinant of melanogenesisSemantic proximity Read ↗

CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1Semantic proximity Read ↗

Melanin Transfer and Fate within Keratinocytes in Human Skin PigmentationSemantic proximity Read ↗

M-INK, a novel tool for visualizing melanosomes and melanocores.Semantic proximity Read ↗

UVA Phototransduction Drives Early Melanin Synthesis in Human MelanocytesSemantic proximity Read ↗

MC1R and NR4A receptors in cellular stress and DNA repair: implications for UVR protection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.