Article

Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanoma

2025-12-29

Abstract excerpt

<h4>ABSTRACT</h4> Progression of cutaneous primary melanoma that arises from melanocytes leads to lethal metastatic disease. Molecular mechanisms that control the growth of primary melanoma in the skin and promote progression are not fully understood. Previously we showed that RAP guanine exchange factors EPAC1/2 (Exchange Protein Activated by cyclic AMP) promote the growth of primary melanoma and loss of depende...

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Literature Corpus work: e1bd0e7a-8306-5870-827c-a6fab664b623
DOI: 10.64898/2025.12.29.696903

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