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Article

Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility.

Cancer research - 1 Jun 2021

de Semir David, Bezrookove Vladimir, Nosrati Mehdi, Dar Altaf A, Miller James R, Leong Stanley P, Kim Kevin B, Liao Wilson, Soroceanu Liliana, McAllister Sean, Debs Robert J, Schadendorf Dirk, Leachman Sancy A, Cleaver James E, Kashani-Sabet Mohammed

Abstract excerpt

Melanoma occurs as a consequence of inherited susceptibility to the disease and exposure to UV radiation (UVR) and is characterized by uncontrolled cellular proliferation and a high mutational load. The precise mechanisms by which UVR contributes to the development of melanoma remain poorly understood. Here we show that activation of nuclear receptor coactivator 3 (NCOA3) promotes melanomagenesis through...

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Identifiers

PMID: 33766890
DOI: 10.1158/0008-5472.CAN-20-3450
PMCID: PMC8178194

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