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<i>In vitro</i> evolution of colistin resistance in the <i>Klebsiella pneumoniae</i> complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics

2020-05-24

Abstract excerpt

The increasing prevalence of multidrug-resistant Gram-negative opportunistic pathogens, including Klebsiella pneumoniae , has led to a resurgence in the use of colistin as a last-resort drug. Colistin is a cationic lipopeptide antibiotic that selectively acts on Gram-negative bacteria through electrostatic interactions with anionic phosphate groups of the lipid A moiety of lipopolysaccharides (LPS). Colistin resi...

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Literature Corpus work
3f16986f-d93b-5350-94d6-fc49c0ad47a1
DOI
10.1101/2020.05.24.112334
Open publication

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<i>In vitro</i> evolution of colistin resistance in the <i>Klebsiella pneumoniae</i> complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristicsDOI 10.1101/2020.05.24.112334
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