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Non-clonal emergence of colistin resistance associated with mutations in the BasRS two-component system in <i>Escherichia coli</i> bloodstream isolates

2019-12-05

Abstract excerpt

Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabilization and cell death. Here, we aimed to uncover the mechanisms of colistin resistance in nine colistin-resistant Escherichi...

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Literature Corpus work
f3c36d1e-76fb-5c0a-953c-2a22b9405846
DOI
10.1101/864983
Open publication

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Non-clonal emergence of colistin resistance associated with mutations in the BasRS two-component system in <i>Escherichia coli</i> bloodstream isolatesDOI 10.1101/864983
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